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2000 Football Schedule/Results
| Date | Opponent | Location | Outcome/Time |
| 08/31/2000 | Missouri Western State College | St. Joseph, Mo. | W, 17-13
Recap | Stats |
| 09/09/2000 | Truman State University | Vermillion, S.D. | W, 38-14
Recap | Stats |
| 09/16/2000 | University of North Dakota | Grand Forks, N.D. | L, 42-14
Recap | Stats |
| 09/23/2000 | North Dakota State University | Fargo, N.D. | L, 45-20
Recap | Stats |
| 09/30/2000 | Augustana College | Vermillion, S.D. | W, 15-10
Recap | Stats |
| 10/07/2000 | St. Cloud State University | St. Cloud, Minn. | W, 37-0
Recap | Stats |
| 10/14/2000 | University of Nebraska-Omaha | Vermillion, S.D. | L, 21-7
Recap | Stats |
| 10/21/2000 | University of Northern Colorado | Vermillion, S.D. | W, 27-6
Recap | Stats |
| 10/28/2000 | Morningside College | Sioux City, Iowa | W, 30-7
Recap | Stats |
| 11/04/2000 | South Dakota State University | Brookings, S.D. | W, 41-28
Recap | Stats |
| 11/11/2000 | Minnesota State University, Mankato | Vermillion, S.D. | W, 24-3
Recap | Stats |
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